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Dicalcium Phosphate

E No.:E450(vi)
CAS NO.:7757-93-9
Einecs No.:231-826-1
Hs code:28352600.00
Payment Term:L/C, D/P, T/T
QC:HACCP, Halal, Kosher, ISO



DCP is an insoluble inorganic diluent. The anhydrous (triclinic crystal) and dihydrate (monoclinic structure) forms of DCP are used in pharmaceutical development (Rowe et al., 2009). The dihydrate form of DCP presents good flow properties and low hygroscopicity. Based on the temperature (40–50°C) and humidity (32%–75% relative humidity: % RH), however, the dihydrate form tends to lose water of hydration, which can cause chemical instability of APIs in dosage forms (Landín et al., 1994; Miyazaki, Sivaprakasam, Tantry, & Suryanarayanan, 2009). Because of the absence of water in its crystal structure, the anhydrous form of DCP exhibits higher porosity, leading to better compressibility and faster disintegration (Doldán, Souto, Concheiro, Martínez-Pacheco, & Gómez-Amoza, 1995). The dihydrate form transforms (partially or wholly) to the anhydrous form because of the high temperature in the wegranulation process.

Comparison between the two forms of DCP showed that the anhydrous form has better intraparticular porosity and better compressibility than the dihydrate form (Doldán et al., 1995). In addition, because of the higher intraparticular porosity, disintegration of anhydrous DCP is better than the dihydrate form. Both forms of DCP, however, needed a swelling-type disintegrant in the formulation when used (Khan & Rooke, 1976). Different grades of DCP are available, with coarse grade used for direct compression and milled grade for wet granulation or roller compaction. The milled grade has an alkaline pH and cannot be used with API incompatible with basic pH.

Product Name: Dicalcium Phosphate Batch No: 18042001  Package: 25kg/Bag
Mfg. Date: 04 Jun.2022  Expi Date: 03 Jun. 2024 Quantity: 5000kg
Item Food Grade Result
Content (As Na4P2O7 on Ignited Basis) ≥ 95.0% 98.7%
Content (As P2O5) 52.5% - 54.0% 52.7%
Loss on Ignition ≤ 0.5% 0.37%
pH Value (1% Solution) 9.8 – 10.8 10.1
Lead ≤ 1 ppm < 1 ppm
Arsenic ≤ 1 ppm < 1 ppm
Cadmium ≤ 1 ppm < 1 ppm
Mercury ≤ 1 ppm < 1 ppm
Fluoride (Expressed as Fluorine) ≤ 10 ppm < 10 ppm
Water Insolubles ≤ 0.2% 0.09%

Dicalcium Phosphate is a calcium phosphate salt of phosphoric acid with the formula: CaHPO4. It is a common additive/ ingredient of products primarily involved in the agriculture (feed ingredient), food, personal care, and medicinal (pharmaceutical additive) industries.

Products that may contain dicalcium phosphate include: tooth paste, pills and tablets, vitamins, chicken feed, and various cosmetic skin products.

Agriculture, Food & Medicinal Applications

Dicalcium phosphate provides animals with the necessary calcium and phosphorous required in their diets. For similar reasons, it is also added to certain cereals, pet edibles, and can even be bought as a dietary supplement.

Personal Care & Cosmetics

Dicalcium phosphate is useful in the personal care department for its opacity, bulking capabilities, and its ability to affect the overall pH of the product. It can be found used in tooth pastes, deodorants, cosmetic foundations, eye makeup, blushes, and other such types of skin care products.

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