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Metronidazole Benzoate

E No.:
CAS NO.:13182-89-3
Einecs No.:236-131-7
Hs code:29332900.90
Payment Term:L/C,D/P,T/T



Metronidazole is a nitroimidazole antibiotic with an anaerobic antibacterial spectrum with antiprotozoal activity against Giardia spp. In an anaerobic environment, metronidazole is converted to unstable intermediates (nitroso free radicals) that disrupt bacterial DNA synthesis. Immunomodulatory properties capable of inhibiting cell-mediated immunity have been described for metronidazole, although its immunomodulatory properties are reported at dosages well beyond what is recommended for clinical use, raising questions about the clinical use of metronidazole as an adjunctive therapy for treating inflammatory bowel disease.

Resistance to metronidazole is considered rare.The most common adverse reaction is gastrointestinal upset, including inappetence, anorexia, nausea, and vomiting. Profuse salivation can occur in cats after oral administration of metronidazole base (formulation used in standard tablets), which has lead to the use of metronidazole benzoate (a compounded formulation not approved by the Food and Drug Administration) in some cats because of its better oral palatability.At high doses (>200 mg/kg/day) benzoic acid is reported to be neurotoxic in cats, but with appropriate clinical dosing of metronidazole benzoate benzoic acid toxicity is unlikely. Dose-related metronidazole toxicity in cats results in cerebellovestibular ataxia secondary to gamma-aminobutyric acid (GABA) inhibition at dosages greater than or equal to 58 mg/kg/day; clinical signs include nystagmus, head tilt, ataxia, seizures, and obtundation.

Take metronidazole exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.

Metronidazole oral is taken by mouth. The injection is given as an infusion into a vein. A healthcare provider will give you the injection if you are unable to take the medicine by mouth.

Shake the oral suspension (liquid). Measure a dose with the supplied measuring device (not a kitchen spoon).

Swallow the extended-release tablet whole and do not crush, chew, or break it.

If you are treating a vaginal infection, your sexual partner may also need to take metronidazole so you don't become reinfected.

Metronidazole is usually given for up to 10 days in a row. You may need to repeat this dosage several weeks later.

Keep using this medicine even if your symptoms quickly improve. Skipping doses could make your infection resistant to medication. This medicine will not treat a viral infection (flu or a common cold).

Metronidazole will not treat a vaginal yeast infection. You may even develop a new vaginal yeast infection, which may need to be treated with antifungal medication. Tell your doctor if you have symptoms such as itching or discharge during or after treatment with this medicine.

Do not share this medicine with another person, even if they have the same symptoms you have.

This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using this medicine.

Store at room temperature away from moisture and heat.

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