Soft capsule is a common form of pharmaceutical packaging, which consists of an outer shell and an inner filling. Thickeners play an important role in the production process of soft capsules. They can increase the viscosity and cohesion of the filling, making the soft capsules more stable and easier to swallow. When choosing a thickener for soft capsules, you need to consider multiple factors, such as thickening effect, safety, production process, etc. This article will explain the role of softgel thickeners, key points of selection, and the best thickeners for softgels.
First of all, the role of thickeners in soft capsules is to increase the viscosity and cohesion of the filling. The outer shell of a softgel is usually made of gelatin, while the inner filling is a drug or nutritional supplement. The more viscous and cohesive a filling is, the better it can maintain the integrity of the drug and avoid flowing or dispersing. In addition, thickeners can also improve the taste and swallowability of soft capsules and improve patients' taking experience.
When choosing a thickener for soft capsules, you need to pay attention to the following points. First of all, the thickener should have a good thickening effect and can effectively improve the viscosity and cohesion of the filling. Secondly, the thickener should have good solubility and dispersion and be able to mix evenly with the filler to ensure the uniformity of the drug. In addition, the thickener should have good stability and be able to maintain its functions and properties during the production process and storage. Finally, the safety of the thickener is also an important consideration. It should comply with relevant drug regulatory standards and not have adverse effects on human health.
So, what kind of thickener is best for soft capsules? According to different fillers and production processes, it is necessary to choose the appropriate thickener. Here are some commonly used thickeners:
Sodium carboxymethylcellulose (CMC-Na): CMC-Na is a water-soluble polymer with good thickening effect and stability. It can form colloids with water or other solvents to increase the viscosity and cohesion of the filling.
To sum up, the thickener of soft capsules plays an important role in the production process. Choosing a suitable thickener requires consideration of thickening effect, safety, solubility and other factors. If you don’t know which thickener to choose, you might as well try kemfood. As a professional thickener manufacturer, kemfood can provide you with high-quality products and perfect services!